6. Interferon restriction of target organs for lymphocytic choriomeningitis virus-induced T lymphocytes may be lethal

Autor:	C. J. Pfau, J. K. Valenti, R. M. Friedman
Rok vydání:	1982
Předmět:	viruses Disease Biology Lymphocytic choriomeningitis medicine.disease biology.organism_classification Virology Newcastle disease Neutralization Virus Viral replication Interferon Immunology medicine Target organ medicine.drug
Zdroj:	Philosophical Transactions of the Royal Society of London. B, Biological Sciences. 299:137-139
ISSN:	2054-0280 0080-4622
Popis:	It is generally held that interferons play a role in recovery from acute primary viral infections. One of the most direct ways that this can be demonstrated is by use of anti-interferon serum. Rapid evolution of lethal disease in a number of murine infections (encephalomyocarditis, herpes simplex, Newcastle disease, Semliki Forest viruses) was observed when interferon liberated from virus-infected cells was neutralized by injection of anti-interferon serum. The neutralization suppressed the normal interferon effect, allowing unchecked dissemination of virus (Gresser et al . 1976 b ). However, it appears to be precisely this antiviral property of interferon that causes death in adult mice infected intracerebrally (i.c.) with lymphocytic choriomeningitis (LCM) virus. We explain here how the rapid proliferation of LCM virus could spare these mice rather than kill them.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3816b45f3cf5780e4e7f4d548ae3650f https://doi.org/10.1098/rstb.1982.0118 Zobrazit plný text záznamu