3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors prevent the progression of renal dysfunction in Japanese hypertensive patients
| Autor: | Yoko Hirakawa, Toru Kubo, Masanori Nishinaga, Kanji Bando, Masanori Kuwabara, Yoshinori Doi, Hiroaki Kitaoka |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Statin medicine.drug_class Cholesterol business.industry medicine.medical_treatment Urology Renal function medicine.disease Hydroxymethylglutaryl-CoA reductase chemistry.chemical_compound Blood pressure Endocrinology chemistry Internal medicine Diabetes mellitus medicine lipids (amino acids peptides and proteins) Hemodialysis business Kidney disease |
| Zdroj: | Geriatrics & Gerontology International. 10:219-224 |
| ISSN: | 1447-0594 1444-1586 |
| Popis: | Aim: The aim was to determine whether the use of statins prevents the progression of chronic kidney disease (CKD) in hypertensive patients. Methods: We retrospectively reviewed data obtained from hypertensive patients, and subjects with diabetes mellitus and those undergoing hemodialysis were excluded. At total of 227 patients were enrolled (83 men, mean age 73 years) and 90% of the patients were of CKD stage 2 or 3. The patients were divided into two groups: those treated with statins (n = 93) and those not treated with statins (n = 134). Renal function was evaluated by estimated glomerular filtration rate (eGFR). Results: The statin group and the non-statin group were similar in age, sex, blood pressure, follow-up period and prescriptions of antihypertensive medicines. The eGFR in the statin group increased from 62 ± 14 to 66 ± 15 (mL/min per 1.73 m2), whereas it decreased in the non-statin group from 69 ± 16 to 64 ± 18 (mL/min per 1.73 m2). The annual eGFR improved in the statin group (2.5 ± 6.6 mL/min per 1.73 m2/year), but decreased in the non-statin group (−3.3 ± 6.6 mL/min per 1.73 m2/year) (P |
| Databáze: | OpenAIRE |
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