Role of Platelet-Derived Growth Factors in Angiogenesis and Alveogenesis
| Autor: | Linda Karlsson, Christer Betsholtz, Per Lindahl, Hans Boström, Mattias Kalén, Mats Hellström |
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| Rok vydání: | 1999 |
| Předmět: |
Platelet-derived growth factor
biology Tyrosine phosphorylation Receptor tyrosine kinase Cell biology Cell membrane chemistry.chemical_compound medicine.anatomical_structure chemistry Immunology medicine biology.protein Binding site Receptor Intracellular part Platelet-derived growth factor receptor |
| Zdroj: | Current Topics in Pathology ISBN: 9783642636035 |
| DOI: | 10.1007/978-3-642-58456-5_4 |
| Popis: | Platelet-derived growth factors (PGDFs) are 30-kDa dimeric proteins that exert their functions by binding to and activating PDGF receptors in the cell membrane [12, 22]. Two different PDGF monomers exist; the A chain and the B chain, and these may assemble into AA and BB homodimers as well as AB heterodimers. The two known PDGF-receptor proteins, the PDGF-α receptor (PDGF-Rα) and the β receptor (PDGF-Rβ) are both receptor tyrosine kinases and interact differentially with the PDGF molecules; PDGF-Rβ binds only the PDGF B chain with high affinity, whereas PDGF-Rα binds both chains with high affinity. Accordingly, the different PDGF dimers may bind to, dimerize and signal through different receptor pairs. Dimerization of the receptors is a prerequisite for signaling, since it allows for tyrosine phosphorylation of the intracellular part of the receptor molecules [11]. The resulting phosphotyrosine residues constitute binding sites for molecules carrying src-homology-2 (SH2) and other phosphotyrosine-binding domains. Their association with the PDGF receptor is a critical step in downstream signaling [5, 13]. |
| Databáze: | OpenAIRE |
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