Stereoselective production of (S)-1-aralkyl- and 1-arylethanols by freshly harvested and lyophilized yeast cells

Autor:	László Poppe, Gábor Seres, Antal Szabó, Balázs Erdélyi, József Ivanics, Laszlo Birincsik, Gábor Szatzker
Rok vydání:	2006
Předmět:	biology Chemistry Stereochemistry Organic Chemistry Absolute configuration biology.organism_classification Catalysis Yeast Zygosaccharomyces rouxii Inorganic Chemistry Enantiopure drug Debaryomyces hansenii Stereoselectivity Physical and Theoretical Chemistry
Zdroj:	Tetrahedron: Asymmetry. 17:268-274
ISSN:	0957-4166
DOI:	10.1016/j.tetasy.2005.12.025
Popis:	Substituted ( S )-1-phenyl- 2a – h and ( S )-1-benzyl-propan-2-ols 4a and b , and ( S )-1-phenylethanol 6 were produced from prochiral ketones 1a – h , 3a , b and 5 by reductions with freshly harvested Zygosaccharomyces rouxii and Debaryomyces hansenii cells. The bioreductions were also performed by lyophilized cells. Comparison of the secondary alcohols from the bioreductions 2b – e , g , h and 4a and authentic ( S )-alcohols ( S )- 2b – e , g , h and ( S )- 4a synthesized from enantiopure ( S )-methyloxirane 7 proved the absolute configuration of the products.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::378efa0f59d571710aa4d13e51bf8fd5 https://doi.org/10.1016/j.tetasy.2005.12.025 Zobrazit plný text záznamu Full Text from ScienceDirect