Differences in Bone Resorption after Menopause in Japanese Women with Normal or Low Bone Mineral Density: Quantitation of Urinary Cross-Linked N-Telopeptides Portions of this work were presented at the 1995 meeting of the American Society for Bone and Mineral Research. -->

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Autoři: Y. Taguchi, Itsuo Gorai, Osamu Chaki, M. Nakayama, M. G. Zhang, Hiroshi Minaguchi
Zdroj: Calcified Tissue International. 62:395-399
Informace o vydavateli: Springer Science and Business Media LLC, 1998.
Rok vydání: 1998
Témata: Bone mineral, medicine.medical_specialty, Bone density, business.industry, Endocrinology, Diabetes and Metabolism, Urinary system, Osteoporosis, medicine.disease, Bone resorption, Menopause, Endocrinology, Internal medicine, Cohort, medicine, Orthopedics and Sports Medicine, Analysis of variance, business, human activities
Popis: The objective of this study was to examine the value of NTx, a urinary cross-linked N-telopeptides of type I collagen, as a marker of bone resorption. We assessed changes in pre- and postmenopausal bone resorption by evaluating the correlation of NTx with L2-4 bone mineral density (BMD) in a total of 1100 Japanese women, aged 19-80 years [272 premenopausal (45.2 +/- 6.2 years) and 828 postmenopausal (59.5 +/- 6.2 years)]. Postmenopausal women were divided into three groups based on the range of BMD (normal, osteopenic, and osteoporotic). Within each group, subjects were further segregated according to years since menopause (YSM). NTx values were then evaluated for each group. Our results showed that BMD was significantly decreased (P < 0.05) and NTx was significantly increased (P < 0.01) after menopause in age-matched analysis. Consistent with a previous report, NTx was inversely correlated with BMD for the entire cohort of study subjects (r = -0.299), although NTx correlated better with premenopausal than postmenopausal BMD (r = -0.240 versus r = -0.086). This may have been due to the fact that elevated values of NTx were exhibited over the entire range of BMD present in the postmenopausal women, suggesting that NTx might respond faster to the estrogen withdrawal than BMD. In all postmenopausal women, regardless of the range of BMD, the increase in NTx reached a peak within 5 YSM. After 11 YSM, however, NTx remained elevated in the osteoporotic group but it decreased in the osteopenic group, and showed no significant change in the group of postmenopausal women with normal BMD. These findings suggest that bone resorption is dramatically increased within 5 years after menopause but remains increased only in osteoporotic women.
ISSN: 1432-0827
0171-967X
DOI: 10.1007/s002239900451
Přístupová URL adresa: https://explore.openaire.eu/search/publication?articleId=doi_________::3785574b6687bae4cae1bafced9ad7ef
https://doi.org/10.1007/s002239900451
Rights: CLOSED
Přírůstkové číslo: edsair.doi...........3785574b6687bae4cae1bafced9ad7ef
Autor: Y. Taguchi, Itsuo Gorai, Osamu Chaki, M. Nakayama, M. G. Zhang, Hiroshi Minaguchi
Rok vydání: 1998
Předmět:
Zdroj: Calcified Tissue International. 62:395-399
ISSN: 1432-0827
0171-967X
DOI: 10.1007/s002239900451
Popis: The objective of this study was to examine the value of NTx, a urinary cross-linked N-telopeptides of type I collagen, as a marker of bone resorption. We assessed changes in pre- and postmenopausal bone resorption by evaluating the correlation of NTx with L2-4 bone mineral density (BMD) in a total of 1100 Japanese women, aged 19-80 years [272 premenopausal (45.2 +/- 6.2 years) and 828 postmenopausal (59.5 +/- 6.2 years)]. Postmenopausal women were divided into three groups based on the range of BMD (normal, osteopenic, and osteoporotic). Within each group, subjects were further segregated according to years since menopause (YSM). NTx values were then evaluated for each group. Our results showed that BMD was significantly decreased (P < 0.05) and NTx was significantly increased (P < 0.01) after menopause in age-matched analysis. Consistent with a previous report, NTx was inversely correlated with BMD for the entire cohort of study subjects (r = -0.299), although NTx correlated better with premenopausal than postmenopausal BMD (r = -0.240 versus r = -0.086). This may have been due to the fact that elevated values of NTx were exhibited over the entire range of BMD present in the postmenopausal women, suggesting that NTx might respond faster to the estrogen withdrawal than BMD. In all postmenopausal women, regardless of the range of BMD, the increase in NTx reached a peak within 5 YSM. After 11 YSM, however, NTx remained elevated in the osteoporotic group but it decreased in the osteopenic group, and showed no significant change in the group of postmenopausal women with normal BMD. These findings suggest that bone resorption is dramatically increased within 5 years after menopause but remains increased only in osteoporotic women.
Databáze: OpenAIRE
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