Rate of decay and distribution volume of MB isoenzyme of creatine kinase, intravenously injected into the baboon

Autor:	D. M. Nicoloff, Walid G. Yasmineh, R B Pyle
Rok vydání:	1976
Předmět:	medicine.medical_specialty biology Experimental model Chemistry Biochemistry (medical) Clinical Biochemistry Rate of decay Body weight Isozyme Endocrinology Internal medicine biology.animal medicine biology.protein Creatine kinase Exponential decay Distribution Volume Baboon
Zdroj:	Clinical Chemistry. 22:1095-1097
ISSN:	1530-8561 0009-9147
DOI:	10.1093/clinchem/22.7.1095
Popis:	We determined the decay constant and distribution space of the MB isoenzyme of creatine kinase after intravenous injection of 440 to 720 U, in a group of seven adult baboons. The rate of decay of the isoenzyme was monoexponential, with a mean decay constant of 0.00175 min-1 (SD, 0.00019). The mean distribution volume obtained by extrapolation of the monoexponential curve to zero time was 5.22% (SD, 1.06) of body weight. We have determined these parameters with the purpose of using this isoenzyme in the baboon as an experimental model for measuring myocardial infarct size.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::37313fe22b1c71ab3de53d5b3195c874 https://doi.org/10.1093/clinchem/22.7.1095 Zobrazit plný text záznamu