A matched case control study in veteran patients with high cardiovascular risk (CVR) examining cardiac medication (CMed) prescribing differences between prostate cancer (PC) patients on androgen deprivation therapy (ADT) and men without PC
| Autor: | Yash Patel, James A Kruer, Angela C. Canfield, Angela D. Reed, Noah M. Hahn, Marietta L. Moore |
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| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Journal of Clinical Oncology. 30:e15179-e15179 |
| ISSN: | 1527-7755 0732-183X |
| Popis: | e15179 Background: Conflicting reports exist on associations between ADT and CVR in PC patients (pts). The current study tests the hypothesis that underutilization of CMeds in PC pts with known CVR contributes to their increased cardiac event rates. Methods: Veteran men without malignancy (no-PC, controls) and men with PC on ADT (cases) were consented through the IUSCC IRB-approved biorepository protocol. All pts had high CVR defined as the presence of > 2 of the following: age > 45, Body mass index (BMI) > 30 kg/m2, hypertension (HTN), hyperlipidemia (HL), diabetes (DM), and smoking history (SmHx). Prior coronary artery disease (CAD) qualified pts as severe CVR. Each case was matched with 2 controls in the following order of priority: prior CAD, HTN, DM, HL, SmHx, age, BMI, and race. CMeds prescriptions included in the table below were verified via VAMC pharmacy records. CMeds prescription differences between cases and controls were tested by one-sided chi-Squared testing for each medication and by logistic regression for different classes of medications. Results: Between 1/2007 and 6/2011, 53 cases and 254 controls were enrolled in the IUSCC VAMC clinics. After 2:1 matching, the final cohort included 53 cases and 106 controls. Demographics included: prior CAD – 27%, HTN – 60%, DM – 31%, HL – 40%, SmHx – 63%, BMI – median 29.7 kg/m2, Age – median 66 yrs. Controls were younger than cases (71.4 yrs cases – 63.1 yrs controls, p |
| Databáze: | OpenAIRE |
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