Systematic study of (MoTa) NbTiZr medium- and high-entropy alloys for biomedical implants- In vivo biocompatibility examination
| Autor: | Muhammad Akmal, Muhammad Afzal, Ahtesham Hussain, Young Ik Lee, Ho Jin Ryu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Polymers and Plastics Biocompatibility Alloy 02 engineering and technology engineering.material 010402 general chemistry 01 natural sciences Materials Chemistry Composite material Ductility Elastic modulus Mechanical Engineering High entropy alloys technology industry and agriculture Metals and Alloys Nanoindentation equipment and supplies 021001 nanoscience & nanotechnology Microstructure 0104 chemical sciences Mechanics of Materials Nickel titanium Ceramics and Composites engineering 0210 nano-technology |
| Zdroj: | Journal of Materials Science & Technology. 78:183-191 |
| ISSN: | 1005-0302 |
| Popis: | In this study, the application of medium- and high-entropy (MoTa)xNbTiZr alloys in biomedical implants was systematically analyzed. The alloy with the best combination of mechanical properties was selected and characterized for in vitro and in vivo response for the first time to examine its biomedical properties. A logarithmic increase in the hardness and the yield strength was observed as a function of the Mo and Ta content. Alloys with up to 0.4 mol fraction of Mo and Ta showed a plastic strain of more than 30 % under compression. The nanoindentation results showed that the addition of Mo and Ta increased the elastic modulus of the system linearly. It was surmised that the addition of Ta and Mo above a critical concentration (mole fraction = 0.4) was unfavorable from a biomedical perspective as it increased the brittleness and elastic modulus and decreased the ductility of the system. Therefore, the (MoTa)0.2NbTiZr alloy is a potential structural material for biomedical implants because of its excellent strength and ductility. The developed alloy was investigated for its corrosion properties and compared with commercial biomedical alloys. Furthermore, the biocompatibility of the alloy was examined using an in vivo examination. The alloy was implanted in the skeletal muscles of mice for four weeks and the histology of the surrounding tissue was studied. The alloy exhibited strong passive behavior in a phosphate buffer solution and non-toxic soft tissue response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect