POS0511 PERIODONTAL STATUS BEFORE DIAGNOSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS PREDICTS CUMULATIVE DISEASE ACTIVITY IN YEARS AFTER TREATMENT INITIATION
| Autor: | A. Plachokova, J. Fransen, M. Koenders, R. M. Thurlings |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Annals of the Rheumatic Diseases. 81:511.1-511 |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/annrheumdis-2022-eular.861 |
| Popis: | BackgroundTransversal cohort studies demonstrated an association between periodontal disease (PD) and rheumatoid arthritis (RA), but it is unknown how this association evolves during the course and treatment of both conditions1.ObjectivesIn this study we compared RA and PD before and after RA diagnosis in patients versus controls and analyzed the relationships between disease course and treatment of both conditions.MethodsRetrospective dental and RA data were analyzed of 95 RA patients from 10 years before up to 10 years after RA diagnosis. Dental data were acquired from general practices and matched healthy control patient data from the university dental college. PD was analyzed via radiographic assessment using the new periodontal classification system from 2017. The relationship was analyzed between PD and RA parameters and treatment.ResultsMore RA patients had severe or very severe PD compared to matched healthy controls, already before RA diagnosis. The fraction of RA patients with severe/very severe PD increased from 23% before diagnosis to 43% 5-10 years after diagnosis. Patients with a more severe PD before RA diagnosis had more tooth loss at last dental follow-up and a higher cumulative DAS28 in the years after diagnosis. Two-thirds of patients with severe/very severe PD received appropriate dental care less frequently than advised by guidelines. Suboptimal dental care was associated with a higher cumulative DAS28.ConclusionPD occurs before RA diagnosis in a proportion of patients. This proportion increases in the years after diagnosis. PD is associated with a decreased response to treatment of RA. A significant number of RA patients with PD receives suboptimal dental care, which is associated with diminished response to RA treatment.References[1]Scher JU, et al. Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis Rheum. 2012 Oct;64(10):3083-94.Figure 1.periodontitis severity in the years before RA diagnosis was scored from stage 1 to 4 (mild, moderate, severe, very severe) according the periodontal classification system from 2017. The time averaged DAS28 was calculated by taking the mean of the available DAS28 scores in the first 10 years after diagnosis and correcting this for the time intervals during which these were acquired. Linear regression analysis was performed. * = P < 0.05.AcknowledgementsJill Hadisurya, Julia van Bergen, Floris Scholle, Isabelle van Dorp, Sabine Oerlemans, Araksya Zakaryan for data collection, Thea van Gaalen for data management.Disclosure of InterestsNone declared. |
| Databáze: | OpenAIRE |
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