Bioactive Metabolites from Indigenous Actinomycetes Isolated from Marine Water
| Autor: | Talat Yasmeen Mujahid, Tanveer Abbas, Iqra Ahmed, Abdul Wahab, Nayyar Mehmood, Syed Abdus Subhan |
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| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
Nutrition and Dietetics Health (social science) Gram-negative bacteria biology Medicine (miscellaneous) Biological activity Human pathogen Pathogenic bacteria Bacterial growth biology.organism_classification Antimicrobial medicine.disease_cause Microbiology Antibiotic resistance Enzyme chemistry medicine General Pharmacology Toxicology and Pharmaceutics |
| Zdroj: | Journal of Pharmacy and Nutrition Sciences. 5:57-63 |
| ISSN: | 1927-5951 2223-3806 |
| DOI: | 10.6000/1927-5951.2015.05.01.9 |
| Popis: | Microbial natural products have continued to play an important role in the discovery of novel chemicals for the development of important therapeutic agents. Actinomycetes form a potent reservoir of biologically active secondary metabolites and enzymes. The need for finding novel bioactive compounds for the development of new therapeutic agents is required due to the emergence of antibiotic resistance among pathogenic bacteria. Actinomycetes are considered as one of the best producers of variety of antagonistic compounds that could serve as potential chemotherapeutic agents. The present study was undertaken to find new antagonistic compounds from actinomycetes. Actinomycetes were successfully isolated from marine water samples collected at various locations of Karachi. Initially 39 isolates were collected out of which 23 were found to produce active metabolites against one or more test bacterial cultures. Actinomycetes strains IS26, IS33, and IS39 showed significant potential of having bioactive metabolites. Further, the spectrum of those strains was tested against gram positive and gram negative bacteria and results showed variable potential of actinomycetes to inhibit bacterial growth. |
| Databáze: | OpenAIRE |
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