The anti-allergic effect of the ethyl acetate fraction from anEcklonia kuromeextract
| Autor: | Teruo Matsushita, Yoshimasa Sugiura, Yuichi Kinoshita, Koki Nagayama, Ryusuke Tanaka |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
Ecklonia kurome biology Immunology Degranulation Ethyl acetate Epigallocatechin gallate biology.organism_classification Phlorotannin Oxazolone chemistry.chemical_compound Phospholipase A2 chemistry Biochemistry biology.protein Arachidonic acid Agronomy and Crop Science Food Science |
| Zdroj: | Food and Agricultural Immunology. 26:181-193 |
| ISSN: | 1465-3443 0954-0105 |
| DOI: | 10.1080/09540105.2014.880665 |
| Popis: | To determine the anti-allergic effects of Ecklonia kurome, the ethyl acetate fraction from an E. kurome (EEK) extract was compared to the ethyl acetate fraction from an Eisenia arborea (EEA) extract and epigallocatechin gallate (EGCG) for inhibitory effects on inflammation in experimental animals, degranulation in inflammatory lymphocytes and enzymatic activities involved in allergic reactions. EEK was found to inhibit mouse ear oedema by inflammatory inducers (arachidonic acid, 12-O-tetradecanoylphorbol-13-acetate and oxazolone) in a dose-dependent manner, through both topical and oral administrations. EEK also inhibited degranulation in rat basophilic leukaemia cells and enzymatic activities (cyclooxygenase-2, soybean lipoxygenase and phospholipase A2) in a dose-dependent manner. The effects of EEK were generally comparable of those of EEA and EGCG. Therefore, E. kurome and the components in EEK have the benefit of being used not only in common foods, but also more widely as a functional food resource i... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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