Adjuvant chemoradiation in resected gallbladder cancer: a prognostic index model for predicting overall survival
| Autor: | Claudio V. Sole, Francisco Larsen, Sebastián Solé, Lorena Vargas, Vicente J. Sole |
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| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty Framingham Risk Score business.industry medicine.disease 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Cohort Clinical endpoint Medicine Stage (cooking) Radical surgery Gallbladder cancer Risk factor business Chemoradiotherapy |
| Zdroj: | Journal of Radiation Oncology. 8:157-162 |
| ISSN: | 1948-7908 1948-7894 |
| DOI: | 10.1007/s13566-019-00382-2 |
| Popis: | Patients with gallbladder cancer (GBC) have a dismal prognosis. We investigated outcomes and risk factors for overall survival (OS) in patients treated with radical surgery and adjuvant chemoradiotherapy (CRT). A total of 212 patients with LAGC (⩾pT3 59% and/or pN+ 52%) were studied. The primary endpoint of the analysis was OS. We constructed a risk scoring system in which points were assigned to each risk factor by dividing each β coefficient in the final model by the lowest β coefficient and rounding to the nearest integer. A risk score was assigned to each subject by adding up the points for each risk factor present. Subjects were then divided into three risk groups based on their risk scores (0 points = low risk, 1–2 points = intermediate risk, 3–6 points = high risk). Median follow-up was 46.2 months (2–235). Five-year OS for the entire cohort was 53%. In multivariate analysis, higher pT stage [HR, 2.43 (1.29–3.68); p = 0.01], R1 resection [HR, 5.06 (3.12–8.19); p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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