Study on the iodine-catalyzed reaction of 3-aminopyrazine-2-carbohydrazide and 2-(arylethynyl)benzaldehydes
| Autor: | Wan-Chen Pan, Jian-Quan Liu, Xiang-Shan Wang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
010405 organic chemistry
Chemistry Organic Chemistry Imine chemistry.chemical_element Carbohydrazide 010402 general chemistry Cleavage (embryo) Iodine 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Reaction temperature Acetylene Drug Discovery |
| Zdroj: | Tetrahedron. 74:1468-1475 |
| ISSN: | 0040-4020 |
| Popis: | At 60 °C in DMSO, the iodine-catalyzed reaction of 3-aminopyrazine-2-carbohydrazide and 2-(arylethynyl)benzaldehydes led hydrazones. Increasing the reaction temperature to 100 °C, the amino and amido still indicated inactive, only the imine took part in the addition of acetylene bond to give 2-arylisoquinolines in high yields with the cleavage of N-N bond unexpectedly under metal-free conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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