Total assignment of the proton and carbon NMR spectra of the alkaloid quindoline - utilization of HMQC-TOCSY to indirectly establish protonated carbon-protonated carbon connectivities

Autor:	Paul L. Schiff, Albert N. Tackie, Timothy D. Spitzer, Gary E. Martin, Gilbert L. Boye, Maged H. M. Sharaf, Ronald C. Crouch
Rok vydání:	1991
Předmět:	Proton biology Organic Chemistry Cryptolepis sanguinolenta chemistry.chemical_element Protonation Pulse sequence Nuclear magnetic resonance spectroscopy Carbon-13 NMR biology.organism_classification Spectral line chemistry Computational chemistry Carbon
Zdroj:	Journal of Heterocyclic Chemistry. 28:2065-2070
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570280850
Popis:	The reisolation of the indoloquinoline alkaloid quindoline (also known as norcryptolepine) from Cryptolepis sanguinolenta is reported. The structure was unequivocally confirmed by two-dimensional nmr methods; the proton and carbon spectra were assigned for the first time. Because of congestion in the proton spectrum HMQC-TOCSY was used as an alternative to the more familiar COSY experiment. In addition to establishing proton-proton connectivities, HMQC-TOCSY affords the added benefit of providing, in an indirect sense, connectivity information between protonated carbons.
Databáze:	OpenAIRE
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