Synthesis of Exclusively Centrostereogenic 1,3-Bidentate Ferrocenyldiphosphane Ligands and Their Use in Enantioselective Hydrogenations

Autor:	Matthias Lotz, Raffael Schuecker, Paul Knochel, Kurt Mereiter
Rok vydání:	2010
Předmět:	Inorganic Chemistry chemistry.chemical_compound Denticity Ferrocene Chemistry Ligand Organic Chemistry Absolute configuration Enantioselective synthesis chemistry.chemical_element Physical and Theoretical Chemistry Medicinal chemistry Palladium
Zdroj:	Organometallics. 29:6503-6508
ISSN:	1520-6041 0276-7333
DOI:	10.1021/om100830m
Popis:	Five representatives of a novel class of 1,3-bidentate and exclusively centrostereogenic ferrocenyldiphosphane ligands were prepared from ferrocene in a five-step sequence. The ligands were tested in rhodium-mediated asymmetric hydrogenations of two alkenes (methyl acetamidocinnamate and dimethyl itaconate) and delivered high product enantioselectivities of up to 96% ee. The coordination behavior of one ligand in its square-planar palladium dichloride complex was studied by X-ray diffraction, and the R absolute configuration was determined from the X-ray anomalous dispersion effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::33c7f3a8b5425910d290227890c2b414 https://doi.org/10.1021/om100830m Zobrazit plný text záznamu