Dehydroepiandrosterone synergizes with antioxidant supplements for immune restoration in old as well as retrovirus-infected mice
| Autor: | Jeongmin Lee, Zhen Zhang, Shuguang Jiang, Ronald R. Watson, David Solkoff, Paula Inserra |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
endocrine system
medicine.medical_specialty Antioxidant Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Dehydroepiandrosterone Biology Biochemistry chemistry.chemical_compound Dehydroepiandrosterone sulfate Internal medicine polycyclic compounds medicine skin and connective tissue diseases Molecular Biology Nutrition and Dietetics Vitamin E Interleukin Immunosenescence Cytokine Endocrinology chemistry human activities hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | The Journal of Nutritional Biochemistry. 9:362-369 |
| ISSN: | 0955-2863 |
| DOI: | 10.1016/s0955-2863(98)00041-2 |
| Popis: | Production of the antioxidant hormone dehydroepiandrosterone (DHEA) declines as immunosenescence develops in the elderly. Very old C57BL/6 female mice, survivors after 71% had died due to aging, were evaluated after DHEA supplementation for 6 weeks. DHEA significantly increased their T-cell proliferation, restored secretion of Th1 cytokines [interleukin (IL)-2], decreased interferon-γ (IFN-γ) production, and normalized secretion of Th2 cytokine (IL-4 and IL-6) by lowered production. Survival was significantly increased in the 29-month-old mice treated by DHEA. Dehydroepiandrosterone sulfate (DHEAS), the storage form of DHEA, has lowered immune dysfunction caused by increased oxidation during LP-BM5 murine retrovirus infection. To assert the synergistic effect of DHEA + antioxidant nutrients, 17-month-old mice were fed with antioxidants or antioxidants + DHEAS for 16 weeks. DHEAS + antioxidants significantly increased B-cell proliferation and IL-2 secretion, and maintained Th2 cytokine secretion and hepatic vitamin E levels nearer to that of old, uninfected mice than antioxidant supplementation alone. Our study suggests that DHEA alone, and especially DHEAS plus antioxidant nutrients, can prevent immune dysfunction in very old and in old, retrovirus-infected mice. |
| Databáze: | OpenAIRE |
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