Utilization of cleavage of the [1]benzofuro[2,3-e][1,2,4]triazine ring for the synthesis of oxygen, nitrogen and sulfur derivatives of [1,2,4]triazine

Autor:	Petr Bednář, Jakub Stýskala, Jan Slouka, Iveta Wiedermannová
Rok vydání:	2003
Předmět:	Hydrogen sulfide Organic Chemistry chemistry.chemical_element Cleavage (embryo) Sulfur Medicinal chemistry Oxygen chemistry.chemical_compound chemistry Nucleophile Furan Hydrogen selenide Organic chemistry Triazine
Zdroj:	Journal of Heterocyclic Chemistry. 40:805-811
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570400509
Popis:	A series of 6-azacytosines 4a-4k and 5a-5c were prepared by nucleophilic cleavage of furan ring of [1]benzofuro[2,3-e][1,2,4]triazine derivative 1. Some of them were used for the preparation of derivatives of [1,2,4]triazolo[4,3-d][1,2,4]triazine (6a-6d) and tetrazolo[1,5-d][1,2,4]triazine (7). The reaction of 1 with hydrogen sulfide afforded the corresponding 6-(2-hydroxyphenyl)-2-phenyl-5-thioxo-4,5-dihydro-1,2,4-tri-azin-3(2H)-one (8), while with hydrogen selenide 6-(2-hydroxyphenyl)-2-phenyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (9) was formed. The prepared compounds were tested for biological activity.
Databáze:	OpenAIRE
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