| Popis: |
The available evidence suggests that dietary advanced glycation end products (AGEs) can increase circulating AGEs. The liver is one of the important organs for metabolism and clearance of the AGEs, which, in turn, is also exposed to the toxic effects of these compounds as a target tissue. It has been suggested that dietary AGEs are one of the important modifiable nutritional factors involved in the pathogenesis of liver diseases. Dietary AGEs, because of the adverse effects on liver histology, liver enzymes, and metabolic and inflammatory profiles, also increase reactive oxygen species production, activate receptor for advanced glycation end products (RAGE) pathway, increase RAGE gene expression, enhance de novo lipogenesis and weight gain can increase the risk of liver disorders. The available evidences indicate that dietary AGEs act as a “cofactor” or the “second hit” in unhealthy liver, thereby increasing the risk of liver damages. Therefore, restricting dietary AGEs may be one of the effective strategies for managing liver disorder, especially in individuals at high risk, including type 2 diabetes patients and/or obese persons. |
