Metabolic and Vascular Risk Factor Variability Over 25 Years Relates to Midlife Brain Volume and Cognition
| Autor: | Zahra Shirzadi, Jennifer Rabin, Lenore J. Launer, R. Nick Bryan, Abdulla Al-Ozairi, Jasmeer Chhatwal, Ebaa Al-Ozairi, John A. Detre, Sandra E. Black, Walter Swardfager, Bradley J. MacIntosh |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Alzheimer's Disease. 91:627-635 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-220340 |
| Popis: | Background: Metabolic and vascular risk factors (MVRF) are associated with neurodegeneration and poor cognition. There is a need to better understand the impact of these risk factors on brain health in the decades that precede cognitive impairment. Longitudinal assessments can provide new insight regarding changes in MVRFs that are related to brain imaging features. Objective: To investigate whether longitudinal changes in MVRF spanning up to 25 years would be associated with midlife brain volume and cognition. Methods: Participants were from the CARDIA study (N = 467, age at year 25 = 50.6±3.4, female/male = 232/235, black/white = 161/306). Three models were developed, each designed to capture change over time; however, we were primarily interested in the average real variability (ARV) as a means of quantifying MVRF variability across all available assessments. Results: Multivariate partial least squares that used ARV metrics identified two significant latent variables (partial correlations ranged between 0.1 and 0.26, p |
| Databáze: | OpenAIRE |
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