A new multifunctional benzimidazole tagged coumarin as ratiometric fluorophore for the detection of Cd2+/F− ions and imaging in live cells
| Autor: | Karuppiah Krishnaveni, Murugan Iniya, Duraisamy Chellappa, Ayyanar Siva, Dharmaraj Jeyanthi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Benzimidazole
Fluorophore 010405 organic chemistry Solvatochromism Ethylenediaminetetraacetic acid 010402 general chemistry Photochemistry 01 natural sciences Fluorescence Atomic and Molecular Physics and Optics 0104 chemical sciences Analytical Chemistry Ion chemistry.chemical_compound chemistry Proton NMR Titration Instrumentation Spectroscopy |
| Zdroj: | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 205:557-567 |
| ISSN: | 1386-1425 |
| Popis: | A novel multifunctional ratiometric fluorescent probe has been designed and synthesized for the selective recognition of Cd2+/F− ions. The probe (3)-((2)-(1H-benzoimidazole-2-yl)-phenylimino) methyl-4-chloro-methyl-2H-chromen-2-ene (BIMC) displays excellent ratiometric responses towards Cd2+/F− ions over the tested cations/anions. The lowest detection limits observed for Cd2+ and F− are 1.5 × 10−10 mol/l and 1.2 × 10−10 mol/l respectively. Job's plot and Electro spray Ionization mass spectral (ESI-MS) studies confirms 1:1 binding stoichiometry of BIMC with Cd2+/F− ions, which is further evidenced by 1H NMR titration studies. The reversibility studies of BIMC with Cd2+ have been investigated using ethylenediaminetetraacetic acid (EDTA). Upon binding to Cd2+/F− ions, the probe features strong ratiometric response in both UV–Visible and fluorescence spectra due to the inhibition of intramolecular charge transfer (ICT). Furthermore, the mechanism of ICT has been rationalized via solvatochromism and DFT calculations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect