Prevalence of Ocular Candidiasis and Candida Endophthalmitis in Patients With Candidemia: A Systematic Review and Meta-Analysis

Autor: Kasidis Phongkhun, Thananop Pothikamjorn, Karan Srisurapanont, Kasama Manothummetha, Anawin Sanguankeo, Achitpol Thongkam, Nipat Chuleerarux, Surachai Leksuwankun, Tanaporn Meejun, Jaedvara Thanakitcharu, Morgan Walker, Shilpa Gopinath, Pattama Torvorapanit, Nattapong Langsiri, Navaporn Worasilchai, Chatphatai Moonla, Rongpong Plongla, Olivia S Kates, Saman Nematollahi, Nitipong Permpalung
Rok vydání: 2023
Předmět:
Zdroj: Clinical Infectious Diseases. 76:1738-1749
ISSN: 1537-6591
1058-4838
Popis: Background Infectious diseases and ophthalmology professional societies have disagreed regarding ocular screening in patients with candidemia. We aimed to summarize the current evidence on the prevalence of ocular candidiasis (OC) and Candida endophthalmitis (CE) according to the standardized definitions. Methods A literature search was conducted from the inception date through 16 October 2022 using PubMed, Embase, and SCOPUS. Pooled prevalence of ocular complications was derived from generalized linear mixed models (PROSPERO CRD42022326610). Results A total of 70 and 35 studies were included in the meta-analysis for OC and concordant CE (chorioretinitis with vitreous involvement), respectively. This study represented 8599 patients with candidemia who underwent ophthalmologic examination. Pooled prevalences (95% CI) of OC, overall CE, concordant CE, and discordant CE were 10.7% (8.4–13.5%), 3.1% (2.1–4.5%), 1.8% (1.3–2.6%), and 7.4% (4.5–12%) of patients screened, respectively. Studies from Asian countries had significantly higher concordant CE prevalence (95% CI) of patients screened (3.6%; 2.9–4.6%) compared with studies from European countries (1.4%; .4–5%) and American countries (1.4%; .9–2.2%) (P Conclusions Prevalence of concordant CE overall and among Asian countries was 2 and 4 times higher than the prevalence previously reported by the American Academy of Ophthalmology (AAO) of
Databáze: OpenAIRE
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