Body Size Accounts for Most Differences in Bone Density Between Asian and Caucasian Women
| Autor: | Desmond E. Thompson, Y. F. He, Philip D. Ross, R. D. Wasnich, Carol Coupland, A J Yates, Pernille Ravn, Michael R. McClung |
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| Rok vydání: | 1996 |
| Předmět: |
musculoskeletal diseases
Bone mineral medicine.medical_specialty Bone density business.industry Endocrinology Diabetes and Metabolism Anthropometry Wrist Endocrinology medicine.anatomical_structure Forearm Internal medicine Cohort medicine Lean body mass Physical therapy Orthopedics and Sports Medicine business Pelvis |
| Zdroj: | Calcified Tissue International. 59:339-343 |
| ISSN: | 1432-0827 0171-967X |
| DOI: | 10.1007/s002239900137 |
| Popis: | We compared bone mineral density (BMD) of the whole body (and subregions: arm, leg, and pelvis), hip, spine, lateral spine, wrist, and forearm among Caucasian and Asian women at four geographic centers (Honolulu, HI; Nottingham, UK; Portland, OR; Copenhagen, Denmark). Data were derived from the baseline examination of 1367 Caucasian and 162 Asian women enrolled in the 1609-subject Early Postmenopausal Interventional Cohort (EPIC) study. After adjusting for age, study site, years postmenopause, and years of estrogen use, BMD was approximately 4–6% lower (P < 0.05) among Asian women at most skeletal sites, but there was no significant difference for wrist or forearm BMD. Adding height, lean body mass, fat mass, and/or quadriceps muscle strength to the regression models reduced the racial differences at most skeletal sites; after these additional adjustments, Asian women had significantly lower BMD only for the lateral spine (−4.4%; P < 0.005), arm (−2.20%; P < 0.05) and leg (−1.65%; P < 0.05), whereas the wrist was significantly greater (4.64%; P < 0.005) for Asian women. Further research is needed to determine why racial differences in BMD persist at certain skeletal sites, but not others, after adjusting for body size. |
| Databáze: | OpenAIRE |
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