ChemInform Abstract: Synthesis of Nevirapine and Its Major Metabolite

Autor:	K. D. Hargrave, Julian Adams, Jana Vitous, Grozinger Karl G, Scot Campbell, S. C. Mauldin, Victor Fuchs
Rok vydání:	2010
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Nevirapine chemistry Scale (ratio) Stereochemistry Metabolite medicine General Medicine Aldehyde Reverse transcriptase medicine.drug
Zdroj:	ChemInform. 26
ISSN:	0931-7597
DOI:	10.1002/chin.199530188
Popis:	Several synthetic methods were developed during the process optimization for the large scale synthesis of nevirapine (1), a non-nucleoside inhibitor of HIV-1 Reverse Transcriptase. The synthesis of its putative major metabolite 11-cyclopropyl-5,11-dihydro-4-hydroxymethyl-6H-[3,2-b:2′,3′-e][1,4]diazepin-6-one (2) and the oxidation of 2 to the corresponding aldehyde 3, are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::31a73d37194b113debe9e5744a08b0a9 https://doi.org/10.1002/chin.199530188 Zobrazit plný text záznamu Plný text