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Objectives: Carbamazepine (CBZ) is an anticonvulsant drug used in the treatment of epilepsy and neuropathic pain. The aim of present study was to develop and evaluate lozenges of Carbamazepine for improvement of bioavailability and patient compliance especially for those patients who have difficulty in swallowing Methods: The lozenges were prepared using sucrose as base; HPMC K4M, methyl cellulose were used as polymers by heating and congealing method on laboratory scale. All the formulations prepared were subjected to various physicochemical parameters like hardness, friability, weight variation, drug content and in vitro dissolution studies. Stability studies of selected formulations of batch CL4 were also carried out at 40/75% relative humidity for 6 months. Results: All the formulations showed good physical appearance. The Thickness of the formulations was in the range of 14.23±0.12 to 14.50±0.06cm, weight variation was found to be in the range of 2.34± 0.12 to 4.51± 0.08%. The percent drug release was found in the range of 55.49 to 93.27%. Selective formulation was found to be stable at different temperature conditions. Conclusion: Study concludes that incorporating polymers like HPMC K4M and methylcellulose can be used to formulate effective medicated Carbamazepine lozenges especially for patients who cannot swallow solid oral dosage forms. Peer Review History: Received 7 September 2017; Revised 19 October; Accepted 1 November, Available online 15 November 2017 Academic Editor: Dr. Asia Selman Abdullah, Al-Razi university, Department of Pharmacy, Yemen, asia_abdullah65@yahoo.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 4.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Dr. Omid Gholami, Sabzevar University of Medical Sciences, Iran, omidghphd@gmail.com Dr. Sameh Abdelmoneem Mohammed Ali, Faculty of Pharmacy, Beni-Suef University, Egypt, same7_pharma18@yahoo.com |
