| Autor: |
Viktor Háda, Andrea Német-Hanzelik, György Keglevich, Hedvig Bölcskei, Zsófia Dubrovay |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Letters in Drug Design & Discovery. 16:1248-1257 |
| ISSN: |
1570-1808 |
| DOI: |
10.2174/1570180816666181106123809 |
| Popis: |
Background: Aryl-methoxybenzaldehydes substituted in various positions may serve as valuable starting materials for the synthesis of biologically active compounds. Methods: Biaryl-methoxybenzaldehydes and pyridyl-aryl-methoxybenzaldehydes were synthesized by the Suzuki-Miyaura cross-coupling reactions as intermediates of potential drug substances. Three different catalytic approaches were compared. The classical Suzuki method utilising tetrakis(triphenylphosphine)palladium and sodium ethoxide, the protocol applying palladium acetate and tri(o-tolyl)phosphine, and the method using tetrakis(triphenylphosphine)palladium and cesium carbonate, were studied. Results: The selected boronic acids were the classical phenylboronic acid, as well as 4-pyridineand 3-pyridineboronic acids. 26 New biaryl-methoxybenzaldehydes or pyridyl-phenylmethoxybenzaldehydes have been synthesized, which may be intermediates for pharmaceutically active compounds. Conclusion: The method of Anderson et al. was preferred, because it provides satisfactory results in all cases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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