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Objective: To describe the situation and analyze some related factors on the patient safety culture of health workers at Vietnam - Cuba Friendship Hospital in 2020 Methods: This is a cross-sectional study that combines qualitative and quantitative methods, conducted at Vietnam - Cuba Friendship Hospital, from February to November 2020. The quantitative research was using HSOPSC toolkit to consult 165 doctors, nurses/technicians; and conducting 12 in-depth interviews. Quantitative data were analyzed by using SPSS software and the qualitative one was recorded, analyzed, and synthesized with each group of influencing factors. Main findings: The overall positive response rate with patient safety culture is 73.9%. The highest positive response rate is 94.2% with “Teamwork within units” dimension and the lowest rated dimension was 50.1% with “Nonpunitive response to error” dimension. The low and middle-income group rated the level of internal safety higher than the high-income group (p = 0.001), and positively response rate to patient safety culture of health workers at Internal Medicine Department is higher than that at Surgery and Subclinical Departments (p |