Assessing the spectrum of germline variation in Fanconi anemia genes among patients with head and neck carcinoma before age 50

Autor:	Settara C. Chandrasekharappa, Adebowale Adeyemo, James W. Thomas, Frank X. Donovan, James C. Mullikin, Holly H. Reid, Steven B. Chinn, Erich M. Sturgis, Qingyi Wei, Naweed I. Chowdhury, Aparna Kamat, Meghana Vemulapalli, Caroline Hussey
Rok vydání:	2017
Předmět:	0301 basic medicine Oncology Cancer Research medicine.medical_specialty education.field_of_study business.industry Population Cancer Bioinformatics medicine.disease Head and neck squamous-cell carcinoma 03 medical and health sciences 030104 developmental biology Germline mutation FANCE Fanconi anemia Internal medicine FANCD2 medicine FANCL education business
Zdroj:	Cancer. 123:3943-3954
ISSN:	0008-543X
DOI:	10.1002/cncr.30802
Popis:	BACKGROUND Patients with Fanconi anemia (FA) have an increased risk for head and neck squamous cell carcinoma (HNSCC). The authors sought to determine the prevalence of undiagnosed FA and FA carriers among patients with HNSCC as well as an age cutoff for FA genetic screening. METHODS Germline DNA samples from 417 patients with HNSCC aged
Databáze:	OpenAIRE
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