CT Perfusion for Determination of Pharmacologically Mediated Blood Flow Changes in an Animal Tumor Model1
| Autor: | Himaja Peddi, Vassilios Raptopoulos, Antoine Hakime, Thierry de Baere, Carol Wilcox, S. Nahum Goldberg, Jonathan B. Kruskal, Shezhang Lin, Andrew Hines-Peralta |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
business.industry
Institutional Animal Care and Use Committee Perfusion scanning Blood flow Laser Doppler velocimetry Neovascularization chemistry.chemical_compound chemistry Medicine Radiology Nuclear Medicine and imaging Tomography Arsenic trioxide medicine.symptom business Nuclear medicine Perfusion |
| Zdroj: | Radiology. 243:712-719 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiol.2433052048 |
| Popis: | Purpose: To prospectively compare single- and multisection computed tomographic (CT) perfusion for tumor blood flow determination in an animal model. Materials and Methods: All animal protocols and experiments were approved by the institutional animal care and use committee before the study was initiated. R3230 mammary adenocarcinoma was implanted in 11 rats. Tumors (18–20 mm) were scanned with dynamic 16-section CT at baseline and after administration of arsenic trioxide, which is known to cause acute reduction in blood flow. The concentration of arsenic was titrated (0–6 mg of arsenic per kilogram of body weight) to achieve a defined blood flow reduction (0%–75%) from baseline levels at 60 minutes, as determined with correlative laser Doppler flowmetry. The mean blood flow was calculated for each of four 5-mm sections that covered the entire tumor, as well as for the entire tumor after multiple sections were processed. Measurements obtained with both methods were correlated with laser Doppler flowmetry ... |
| Databáze: | OpenAIRE |
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