| Autor: |
ANDREAS LEIHERER, AXEL MUENDLEIN, EVA MARIA BRANDTNER, CHRISTOPH H. SAELY, ALEXANDER VONBANK, ARTHUR MADER, LUKAS SPRENGER, MAXIMILIAN MAECHLER, BARBARA LARCHER, ANTTI JYLHA, MITJA LAAPERI, REIJO LAAKSONEN, WINFRIED MAERZ, PETER FRAUNBERGER, MARCUS KLEBER, HEINZ DREXEL |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Diabetes. 71 |
| ISSN: |
0012-1797 |
| DOI: |
10.2337/db22-209-or |
| Popis: |
Serum lipids and metabolic diseases, in particular type 2 diabetes (T2D) and nonalcoholic fatty liver disease (NAFLD) , predict the atherosclerotic diseases coronary artery disease (CAD) and peripheral arterial disease (PAD) . However, it is not known in how far a more detailed characterization including serum lipids improves discrimination of PAD from CAD. A cohort of 274 statin-naïve patients with either PAD (n = 89) or stable CAD (n = 185) were referred to metabolic screening and were characterized using nuclear magnetic resonance- and liquid chromatography-tandem mass spectrometry based advanced lipid and lipoprotein analysis. Results were validated in an independent cohort of 1239 patients with PAD or CAD. We found a significant difference in T2D prevalence and in the ceramide-based lipid profile between PAD and CAD patients. However, neither cholesterol-based markers (including LDL-C, HDL-C) and detailed lipoprotein profiles nor the NAFLD status differed significantly between PAD and CAD patients (figure) . The difference between ceramide-based lipid profiles of CAD and PAD remained significant also after adjusting for body composition, smoking, inflammatory parameters, and T2D. We conclude that PAD and CAD differ in ceramide-based lipid profiles and T2D status, but not in other lipid characteristics or metabolic diseases. Disclosure A.Leiherer: None. A.Jylha: None. M.Laaperi: None. R.Laaksonen: None. W.Maerz: None. P.Fraunberger: None. M.Kleber: None. H.Drexel: None. A.Muendlein: None. E.Brandtner: None. C.H.Saely: None. A.Vonbank: None. A.Mader: None. L.Sprenger: None. M.Maechler: None. B.Larcher: None. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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