Evaluation of the Effect of C-phycocyanin on Cultured Rat Primary Hippocampal Astrocytes Undergoing Trophic Factor Deprivation
| Autor: | Su Jin Yoon, Jung Il Choi, Hwa Sung Shin, Seul Ki Min |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
medicine.medical_specialty Antioxidant medicine.medical_treatment Biomedical Engineering Bioengineering C-Phycocyanin Brain damage Hippocampal formation 01 natural sciences Applied Microbiology and Biotechnology Nitric oxide Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound Downregulation and upregulation 010608 biotechnology Internal medicine medicine 030304 developmental biology Trophic level 0303 health sciences biology Chemistry Endocrinology biology.protein medicine.symptom Biotechnology |
| Zdroj: | Biotechnology and Bioprocess Engineering. 24:870-875 |
| ISSN: | 1976-3816 1226-8372 |
| DOI: | 10.1007/s12257-019-0102-x |
| Popis: | Hippocampal astrocytes play a pivotal role in hippocampal functions. However, trophic factor deprivation during brain injury or neurodegenerative diseases leads to abnormal functions. C-phycocyanin (C-Pc) is an antioxidant compound derived from Spirulina. C-Pc has been studied as a neuroprotectant against brain damage and diseases, however, its effects on hippocampal astrocytes cultured under trophic factor deprivation are unclear. Presently, serum deprivation lowered the metabolic activities, decreasing NADPH diaphorase activity, and decreased production of superoxide dismutase in astrocytes. These effects were reversed after C-Pc treatment. The upregulated NADPH diaphorase activity in activated astrocytes resulted in the increased production of nitric oxide, which protected the hippocampal astrocytes from the harsh trophic factor-deprived environment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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