N-(4-Nitrophenyl)oxamic Acid and RelatedN-Acylanilines Are Non-competitive Inhibitors ofvibrio choleraesialidase but do not inhibittrypanosoma cruziortrypanosoma bruceitrans-sialidases
| Autor: | Armando J. Parodi, Markus Engstler, Roland Schauer, Xiaoying Zhu, Thomas Storz-Eckerlin, Miguel Angel Ferrero-García, Andrea Vasella, Christian Witzig |
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| Rok vydání: | 1994 |
| Předmět: |
inorganic chemicals
animal structures Stereochemistry Nitro compound Trypanosoma brucei medicine.disease_cause Sialidase Biochemistry Catalysis Inorganic Chemistry Vibrionaceae parasitic diseases Drug Discovery medicine Physical and Theoretical Chemistry Trypanosoma cruzi chemistry.chemical_classification biology Chemistry Organic Chemistry biology.organism_classification carbohydrates (lipids) enzymes and coenzymes (carbohydrates) Enzyme Vibrio cholerae Enzyme inhibitor biology.protein |
| Zdroj: | Helvetica Chimica Acta. 77:1166-1174 |
| ISSN: | 0018-019X |
| DOI: | 10.1002/hlca.19940770425 |
| Popis: | N-(4-Nitrophenyl)oxamic acid 1, N-(2-fluoro-4-nitrophenyl)oxamic acid 7, N-(4-nitrophenyl)-trifluoroacetamide 3, and N-(2-methoxy-4-nitrophenyl)trifluoroacetamide 9 are non-competitive inhibitors of Vibrio cholerae sialidase with Ki-values ranging from 2.66 to 5.18 · 10−4M. These compounds, and the N-acetylneuraminic-acid analogues 11–13 do not inhibit the sialidase and trans-sialidase activities from Trypanosoma cruzi; nor does N-(4-nitrophenyl)oxamic acid (1) inhibit the corresponding enzyme activities from T. brucei. |
| Databáze: | OpenAIRE |
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