Effect of oxytocin on nitric oxide activity controlling gonadotropin secretion in humans
| Autor: | M.G. Magotti, Luigi Capretti, Riccardo Volpi, Paolo Chiodera, Gloria Saccani-Jotti, M. L. Bortesi, Guido Manfredi, Vittorio Coiro |
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| Rok vydání: | 2003 |
| Předmět: |
endocrine system
medicine.medical_specialty medicine.drug_class Clinical Biochemistry General Medicine Biology Biochemistry Nitric oxide Gonadotropin secretion Nitric oxide synthase chemistry.chemical_compound Follicle-stimulating hormone Endocrinology Bolus (medicine) chemistry Oxytocin Internal medicine medicine biology.protein Gonadotropin Hormone medicine.drug |
| Zdroj: | European Journal of Clinical Investigation. 33:402-405 |
| ISSN: | 0014-2972 |
| DOI: | 10.1046/j.1365-2362.2003.01122.x |
| Popis: | Background Previously described inhibitory effects of the nitric oxide synthase (NOS) inhibitor L-NAME on luteinizing hormone-releasing hormone (LH-RH)-induced LH and follicle stimulating hormone (FSH) secretion in humans suggested modulation by nitric oxide (NO) of the gonadotropin-releasing action of LH-RH. Design In order to establish whether oxytocin (OT) participates in this regulatory mechanism, 10 normal men were treated with LH-RH (100 micro g as an i.v. bolus) given alone or in the presence of L-NAME (40 micro g kg-1 injected plus 50 micro g kg-1 infused i.v. for 60 min), OT (2 IU injected plus 4 IU infused i.v. for 60 min) or a combination of both drugs. Results The administration of OT was unable to change the gonadotropin responses to LH-RH. In contrast, L-NAME significantly reduced both FSH and LH increments induced by LH-RH. When L-NAME was given in the presence of OT, the LH and FSH responses to LH-RH were similar to those observed after the administration of LH-RH alone. Conclusion These data suggest antagonistic actions of OT and L-NAME in the control of NOS activity in regulation of gonadotropin secretion induced by LH-RH. |
| Databáze: | OpenAIRE |
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