Formulation Optimization and Evaluation of Microemulsion Based Transdermal Therapeutic System for Nitrendipine

Autor:	Yamsani Madhusudan Rao, Ramesh Gannu
Rok vydání:	2012
Předmět:	Chromatography Polymers and Plastics Permeation Box–Behnken design Surfaces Coatings and Films Bioavailability chemistry.chemical_compound chemistry Nitrendipine Pulmonary surfactant medicine Microemulsion Physical and Theoretical Chemistry Isopropyl myristate medicine.drug Transdermal
Zdroj:	Journal of Dispersion Science and Technology. 33:223-233
ISSN:	1532-2351 0193-2691
DOI:	10.1080/01932691.2011.561164
Popis:	Microemulsion based transdermal therapeutic system (TTS) for nitrendipine was developed and evaluated with the aim to improve bioavailability and further therapeutic efficacy. Pseudoternary phase diagrams were constructed for the microemulsions composed of isopropyl myristate (IPM), cremophor and propylene glycol (SMix) as oil, surfactant, and cosurfactant, respectively. Box-Behnken statistical design was employed to optimize the formulations. IPM, SMix and water; cumulative amount permeated across skin, flux, and lag time were selected as independent and dependent variables, respectively. The formulations were evaluated for permeation parameters across rat abdominal skin using Franz diffusion cells. Mathematical equations and response surface plots were used to relate the dependent and independent variables. The flux of optimized formulation could meet target flux. The optimized formulation was further formulated as reservoir system (ME-TTS) and evaluated for in vivo bioavailability in rabbits. The bioav...
Databáze:	OpenAIRE
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