Gemcitabine Delivery and Photodynamic Therapy in Cancer Cells via Porphyrin-Ethylene-Based Periodic Mesoporous Organosilica Nanoparticles
| Autor: | Jean-Olivier Durand, Sébastien Richeter, Marie Maynadier, Jonas G. Croissant, Laure Lichon, Makhlouf Boufatit, Marcel Garcia, Laurence Raehm, Chiara Mauriello Jimenez, Danielle Laurencin, Dina Aggad, Soraya Dib, Shahad Alsaiari, Magali Gary-Bobo, Niveen M. Khashab |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
Membrane permeability medicine.medical_treatment Energy Engineering and Power Technology Nanotechnology Photodynamic therapy 02 engineering and technology 010402 general chemistry 01 natural sciences Gemcitabine Hydrochloride Biomaterials chemistry.chemical_compound Materials Chemistry medicine Photosensitizer Renewable Energy Sustainability and the Environment 021001 nanoscience & nanotechnology Porphyrin Gemcitabine 0104 chemical sciences Mesoporous organosilica chemistry Cancer cell Cancer research 0210 nano-technology medicine.drug |
| Zdroj: | ChemNanoMat. 4:46-51 |
| ISSN: | 2199-692X |
| Popis: | Gemcitabine hydrochloride is an FDA-approved chemotherapeutic drug used in the treatment of various cancers. Several drawbacks of gemcitabine including its short in vivo half-life of 8-17 min associated with a rapid excretion by the kidneys and its poor membrane permeability have inspired research on a nanodelivery approach. In this study, we report ethylene-based periodic mesoporous organosilica nanoparticles (PMOs) for photodynamic therapy and the autonomous delivery of gemcitabine in cancer cells. Porphyrins were used as photosensitizers and were localized in the walls of the PMOs while a high loading capacity of gemcitabine was observed in the porous structure. Depending on the nature of the photosensitizer, and its aggregation state, we were able to perform one or two-photon photodynamic therapy. Two-photon excited photodynamic therapy combined with gemcitabine delivery led to a synergy and a very efficient cancer cell killing. |
| Databáze: | OpenAIRE |
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