Adduction induces large optic nerve head deformations in subjects with normal-tension glaucoma
| Autor: | Thanadet Chuangsuwanich, Tin A Tun, Fabian A Braeu, Xiaofei Wang, Zhi Yun Chin, Satish K Panda, Martin Buist, Dan Milea, Nicholas Strouthidis, Shamira Perera, Monisha Esther Nongpiur, Tin Aung, Michael J A Girard |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | British Journal of Ophthalmology. :bjo-2022 |
| ISSN: | 1468-2079 0007-1161 |
| DOI: | 10.1136/bjo-2022-322461 |
| Popis: | PurposeTo assess intraocular pressure (IOP)-induced and gaze-induced optic nerve head (ONH) strains in subjects with high-tension glaucoma (HTG) and normal-tension glaucoma (NTG).DesignClinic-based cross-sectional study.MethodsThe ONH from one eye of 228 subjects (114 subjects with HTG (pre-treatment IOP≥21 mm Hg) and 114 with NTG (pre-treatment IOPResultsAcross all subjects, adduction generated high effective strain (4.4%±2.3%) in the LC tissue with no significant difference (p>0.05) with those induced by IOP elevation (4.5%±2.4%); while abduction generated significantly lower (p=0.01) effective strain (3.1%±1.9%). The lamina cribrosa (LC) of HTG subjects exhibited significantly higher effective strain than those of NTG subjects under IOP elevation (HTG: 4.6%±1.7% vs NTG: 4.1%±1.5%, pConclusionWe found that NTG subjects experienced higher strains due to adduction than HTG subjects, while HTG subjects experienced higher strain due to IOP elevation than NTG subjects—and that these differences were most pronounced in the LC tissue. |
| Databáze: | OpenAIRE |
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