ВЛИЯНИЕ МЕЛАКСЕНА НА ПОКАЗАТЕЛИ ПЕРЕКИСНОГО ОКИСЛЕНИЯ ЛИПИДОВ И АНТИОКСИДАНТНОЙ ЗАЩИТЫ В ЭКСПЕРИМЕНТЕ ПРИ ХРОНИЧЕСКОМ ОДОНТОГЕННОМ ОСТЕОМИЕЛИТЕ ЧЕЛЮСТЕЙ
| Autor: | K. I. Aliev, G. V. Toboev |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Antioxidant business.industry Osteomyelitis Standard treatment Mandibular osteomyelitis medicine.medical_treatment medicine.disease medicine.disease_cause General Biochemistry Genetics and Molecular Biology Odontogenic Lipid peroxidation chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine General Agricultural and Biological Sciences business Standard therapy Oxidative stress |
| Zdroj: | Siberian Journal of Life Sciences and Agriculture. 11:118 |
| ISSN: | 2658-6657 2658-6649 |
| DOI: | 10.12731/2658-6649-2019-11-4-118-126 |
| Popis: | The study was performed on 50 male Wistar rats, weighing 200–300 grams. A model of odontogenic mandibular osteomyelitis was created in all the animals, except the background group. In the control group, the standard treatment of this pathology was performed. In addition to the standard therapy, the experimental group of rats was injected with the drug Melaxen. On the 40rd, 45th, 50th, 55th days of the experiment, the indices of lipid peroxidation (LPO) and antioxidant protection were studied to determine the stage of inflammation development and the formation of protective reactions of the body. It has been shown that standard therapy of odontogenic osteomyelitis contributes to a certain decrease in the activity of oxidative stress enzymes and an increase in LPO. The use of the drug «Melaxen» led to a significantly more pronounced decrease in indicators of LPO and activation of antioxidant protection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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