| Popis: |
In addition to his widely recognized endocrine effects on the calcium, phosphate, PTH metabolism, vitamin D has many other pleiotropic effects on the vascular function, blood pressure, proteinuria, insulin resistance, lipid metabolism, inflammation, immunity which all may play a role in the progression of renal failure. Angiotensin-converting enzyme inhibitors (ACEi) for renin-angiotensin-aldosterone system (RAAS) blockade are routinely used to slow CKD progression. Natural vitamin D and active vitamin D analogs may further reduce proteinuria in CKD patients in addition to these current treatment regimens. The inverse correlation of blood pressure and vitamin D plasma levels as well as promising data from small intervention studies of vitamin D supplementation provide a rationale for well performed RCT addressing efficacy and safety of vitamin D in hypertension/cardiovascular diseases. Unfortunately, up to now three RCT have not been able to support this. |
