First 97Ru complex with pyridine-2,6-dicarboxamide conjugate for potential use as radiopharmaceutical
| Autor: | Nataliya E. Borisova, Varvara K. Dolgova, Valery A. Knizhnikov, A. P. Orlov, Marina D. Reshetova, Marina A. Orlova |
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| Rok vydání: | 2021 |
| Předmět: |
Methionine
010405 organic chemistry Peptidomimetic Ligand Transport pathways chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Ruthenium chemistry.chemical_compound chemistry Pyridine Distribution (pharmacology) Conjugate |
| Zdroj: | Mendeleev Communications. 31:207-209 |
| ISSN: | 0959-9436 |
| DOI: | 10.1016/j.mencom.2021.03.020 |
| Popis: | A new peptidomimetic conjugate of natural methionine and pyridine-2,6-dicarboxylate was synthesized and evaluated as a potential ligand for 97Ru radiopharmaceuticals. The distribution of this radiopharmaceutical in mice was investigated. A fundamental difference was found in the distribution and excretion of ruthenium complex and free ruthenium ion in the body, which suggests a difference in their transport pathways due to the stability of the complex in the body. |
| Databáze: | OpenAIRE |
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