Immunocytochemical assessment of FKBP51 and Glucocorticoid receptor localization in asthmatic patients
| Autor: | Jabbar H. Yenzeel, Sura F. Alsaffar, Haider F. Ghazi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
General Computer Science business.industry Lymphocyte medicine.medical_treatment Immunocytochemistry General Chemistry medicine.disease General Biochemistry Genetics and Molecular Biology Steroid medicine.anatomical_structure Glucocorticoid receptor Endocrinology Internal medicine Mole medicine Distribution (pharmacology) business Asthma Hormone |
| Zdroj: | Iraqi Journal of Science. :2609-2617 |
| ISSN: | 2312-1637 0067-2904 |
| DOI: | 10.24996/ijs.2019.60.12.9 |
| Popis: | Asthma is a chronic inflammatory disease affecting 5% of the world population. FKBP51 is an important immunophilin modular protein of the glucocorticoid receptor (GC). The aim of the present study was to evaluate the levels and immunocytochemical distribution of FKBP51 and GR in lymphocyte cells of asthmatic patients, by use of immunocytochemistry method, and to assesslevels ofstress hormones (cortisol and ACTH) by radioimmuniassay (RIA). The results showed significantly increased nuclear localization and decreasedcytoplasmic distribution of FKBP51, while they showed a significant increase in nuclear localization and a non-significant decrease in cytoplasmic distribution of GRin asthmatic patients(P |
| Databáze: | OpenAIRE |
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