Analysis of vibrational modes from alpha-synuclein: a theoretical model using density functional theory and Raman spectroscopy
| Autor: | Miguel G. Ramírez-Elías, Martin O. Mendez, Ricardo A. Guirado-López, Alfonso Alba, Ildelfonso Rodríguez-Leyva, Fabiola León-Bejarano |
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| Rok vydání: | 2019 |
| Předmět: |
Alpha-synuclein
Physics Biomedical Engineering A protein Bioengineering Applied Microbiology and Biotechnology nervous system diseases chemistry.chemical_compound symbols.namesake Nuclear magnetic resonance nervous system chemistry Molecular vibration Synuclein symbols Density functional theory Raman spectroscopy Biotechnology |
| Zdroj: | Health and Technology. 10:465-470 |
| ISSN: | 2190-7196 2190-7188 |
| Popis: | Parkinson’s disease is a neurodegenerative pathology difficult to diagnose. Researches have confirmed the presences of death cells in the brain produced by the modification of a protein called alpha-synuclein synuclein in people with Parkinson disease. Currently, a great amount of research is conducted to identify its biomarkers for early diagnostics. Recently, a studio found differences between the alpha- synuclein of the skin from Parkinson’s disease and normal patients. In this paper, we use Raman spectroscopy through a numerical model to simulate the vibrational modes of well-defined finite clusters of alpha-synuclein in normal and pathological state, using the Gaussian09 software. The results of the model in the range of x − y cm−1 are in good agreement with the experimental Raman spectra acquired from human skin with alpha-synuclein in the normal and pathological state. |
| Databáze: | OpenAIRE |
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