Maladie osseuse de Paget : actualités diagnostiques et thérapeutiques
| Autor: | R. Alaya, Zeineb Alaya, E. Bouajina, M. Nang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Pathology medicine.medical_specialty business.industry Osteoporosis Gastroenterology 030209 endocrinology & metabolism Disease Bioinformatics medicine.disease Pathophysiology Metabolic bone disease Pathogenesis Geographic distribution 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Epidemiology Internal Medicine medicine business |
| Zdroj: | La Revue de Médecine Interne. 39:185-191 |
| ISSN: | 0248-8663 |
| DOI: | 10.1016/j.revmed.2017.05.010 |
| Popis: | Paget's disease of bone is the second most common metabolic bone disease after osteoporosis. Its pathogenesis is not yet clearly understood. Geographic distribution and epidemiological variations suggest a role of genetic and environmental factors in its pathophysiology. The frequency of the Paget's disease of bone increases with age. Its discovery can be fortuitous. Prognosis mainly depends on the occurrence of complications involving bones and joints, neurological, cardiovascular or metabolic systems. Treatment of symptomatic forms currently relies on bisphosphonates that have transformed its prognosis. |
| Databáze: | OpenAIRE |
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