Lipoprotein lipase as humoral agent of the physiological anticlotting system
| Autor: | V. N. Nosova, G. G. Bazaz'yan, B. A. Kudryashov, S. S. Trapeznikova |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Lipoprotein lipase biology General Medicine Heparin General Biochemistry Genetics and Molecular Biology Endocrinology Thrombin Enzyme Fat diet chemistry Internal medicine medicine biology.protein Lipase Lipoprotein lipase activity medicine.drug Lipoprotein |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 55:493-496 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Experiments were staged on 450 male albino rats. As established, a stable food lipemia was attained after keeping the animals on a fat diet (according to Wilgram [42,43]) for 8 months. The activity of lipoprotein plasma lipase in such animals was half as compared to control animals which were given the usual laboratory ration. Intravenous injection of heparin led to considerable activation of lipoprotein lipase in experimental animals. However, it did not reach the level attained in control animals after injection of the same doses of heparin. Intravenous injection of thrombin to normal animals led to activation of lipoprotein lipase due to the appearance in the blood of some excess of reflex-secreten heparin by the physiological anticoagulating system [4, 7, 10] in response to the appearance of thrombin in the circulation. Thus, the development of prethrombotic state in animals kept on a fat diet was accompanied by reduction of lipoprotein lipase activity due to deficiency of heparin and partially of the enzyme itself. A conclusion was drawn that lipoprotein lipase was connected with the function of the physiological anticoagulating system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink