Association ofTIMP-2Rs8179090 Genotypes With Lung Cancer Risk in Taiwan

Autor:	Wen-Shin Chang, Te Chun Hsia, Yi-Cheng Shen, Yun-Chi Wang, Da Tian Bau, Wei-Chih Liao, Chia-Wen Tsai, Mei-chin Yin, Chien-Wen Huang
Rok vydání:	2021
Předmět:	Cancer Research Single-nucleotide polymorphism General Medicine Biology Matrix metalloproteinase medicine.disease Molecular biology Lung cancer susceptibility Genotype frequency Oncology Polymorphism (computer science) Genotype medicine Allele Lung cancer
Zdroj:	Anticancer Research. 41:5425-5430
ISSN:	1791-7530 0250-7005
DOI:	10.21873/anticanres.15354
Popis:	Background/aim The tissue inhibitor of metalloproteinase-2 (TIMP-2) is a critical inhibitor of matrix metalloproteinases (MMPs). Along with MMPs, TIMP-2 regulates the breakdown and remodeling of the extracellular matrix (ECM) and basement membranes. This study investigated the role of genotypes of the TIMP-2 -418G/C (rs8179090) single nucleotide polymorphism on lung risk. Materials and methods A total of 358 lung cancer patients and 716 healthy subjects were recruited in this study. Genotypes were identified via the polymerase chain reaction-restriction fragment length polymorphism methodology. Results The distribution of alleles and genotype frequencies of TIMP-2 -418G/C genotypes between the two groups were compared and no statistically significant difference (p>0.05) was found. The heterozygous and homozygous variant genotypes showed no differential distribution between the control and case groups (p>0.05). Conclusion TIMP-2 -418G/C variants might not be associated with lung cancer susceptibility and could not serve as predictors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2b0e11e850923b212397869ee2cb0c84 https://doi.org/10.21873/anticanres.15354 Zobrazit plný text záznamu