Application of Fluorescence-Guided Surgery to Subsurface Cancers Requiring Wide Local Excision
| Autor: | Kayla Marra, Eric Henderson, David F Bauer, Brent D. Bates, Ethan P. M. LaRochelle, Jonathan T. Elliott, Brian W. Pogue, Dipak B. Ramkumar, Keith D. Paulsen, Jason R. Gunn, Kimberley S. Samkoe, Joachim Feldwisch |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Positive margin business.industry Wide local excision medicine.medical_treatment Hematology General Medicine medicine.disease 030218 nuclear medicine & medical imaging 3. Good health Surgery Resection Visualization 03 medical and health sciences 0302 clinical medicine Image-guided surgery Oncology IRDye 800CW 030220 oncology & carcinogenesis Medicine Affibody molecule Sarcoma business |
| Zdroj: | Cancer Control. 25:107327481775233 |
| ISSN: | 1073-2748 |
| DOI: | 10.1177/1073274817752332 |
| Popis: | The excision of tumors by wide local excision is challenging because the mass must be removed entirely without ever viewing it directly. Positive margin rates in sarcoma resection remain in the range of 20% to 35% and are associated with increased recurrence and decreased survival. Fluorescence-guided surgery (FGS) may improve surgical accuracy and has been utilized in other surgical specialties. ABY-029, an anti-epidermal growth factor receptor Affibody molecule covalently bound to the near-infrared fluorophore IRDye 800CW, is an excellent candidate for future FGS applications in sarcoma resection; however, conventional methods with direct surface tumor visualization are not immediately applicable. A novel technique involving imaging through a margin of normal tissue is needed. We review the past and present applications of FGS and present a novel concept of indirect FGS for visualizing tumor through a margin of normal tissue and aiding in excising the entire lesion as a single, complete mass with tumor-free margins. |
| Databáze: | OpenAIRE |
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