Radiotracers for a multi-target approach to the diagnosis of Alzheimer's disease
| Autor: | Jogeshwar Mukherjee, Daphne Collins, Kathy Kim, Crystal Wang, Rama Pichika, Elizabeth Head, Portia Trinidad, Ines Chen, Balasubramaniam Easwaramoorthy, Neil Saigal, Vivien L. Nguyen |
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| Rok vydání: | 2007 |
| Předmět: |
Chemistry
Organic Chemistry Disease medicine.disease Biochemistry Analytical Chemistry Norepinephrine Nicotinic agonist Degenerative disease Dopamine receptor D2 Drug Discovery medicine Radiology Nuclear Medicine and imaging Serotonin Alzheimer's disease Receptor Neuroscience Spectroscopy medicine.drug |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 50:375-379 |
| ISSN: | 1099-1344 0362-4803 |
| DOI: | 10.1002/jlcr.1266 |
| Popis: | Development of β-amyloid plaques and neurofibrillary tangles is the hallmark of Alzheimer's disease (AD) and progressively affects the overall functioning of the brain. Noninvasive imaging methods aiding early diagnosis will significantly improve benefits provided by treatments and possibly lead to prevention of AD. We report the development of PET radiotracer methods for β-amyloid plaques and tangles, nicotinic α4β2 receptors, serotonin 5HT1A receptors, dopamine D2/D3 receptors and norepinephrine transporters for the study of AD. This multi-target approach is currently being evaluated in AD transgenic mice models. Copyright © 2007 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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