Oral Antibiotic Transition in Patients with Bacteremia with a Urinary Source Due to Extended-Spectrum β-Lactamase-Producing Escherichia coli
| Autor: | Miki Nagao, Taro Noguchi, Masaki Yamamoto, Tsunehiro Shimizu, Yasuhiro Tsuchido, Koh Shinohara, Yasufumi Matsumura, Akihiko Hayashi, Michiko Hayashi, Satomi Yukawa, Yutaka Yamada |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty business.industry medicine.drug_class medicine.medical_treatment Urinary system Hazard ratio Antibiotics Retrospective cohort study General Medicine medicine.disease Confidence interval Infectious Diseases Intravenous therapy Internal medicine Bacteremia Propensity score matching medicine business |
| Zdroj: | Japanese Journal of Infectious Diseases. 75:205-208 |
| ISSN: | 1884-2836 1344-6304 |
| DOI: | 10.7883/yoken.jjid.2020.1084 |
| Popis: | Transitioning from intravenous to oral antibiotic therapy for Escherichia coli bacteremia could reduce the length of hospital stay and drug costs without compromising efficacy. Despite the expansion of extended-spectrum β-lactamase (ESBL)-producing E. coli, only limited data are available regarding the effectiveness of switching to oral antibiotic therapy in patients with bacteremia caused by this organism. To compare clinical outcomes between oral transition therapy and intravenous therapy in patients with bacteremia due to ESBL-producing E. coli with a urinary source, we conducted a retrospective cohort study at 3 Japanese hospitals. Effects were estimated by Cox hazard analysis using propensity scores. Among 996 patients with bacteremia due to E. coli, 73 were included. In the adjusted analysis weighted by propensity scores including 26 patients in the oral switch group and 47 in the intravenous group, oral transition did not increase the risk of treatment failure within 60 days (adjusted hazard ratio 0.86, 95% confidence interval 0.18-4.10), whereas the length of hospital stay was shorter in the oral switch group than in the intravenous group (median, 12 days vs. 19 days, P=0.04). Intravenous-to-oral transition may be an effective treatment option that shortens the hospital stay. |
| Databáze: | OpenAIRE |
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