Influence of Surgical Treatment and Neoadjuvant Therapy of Chemically Induced Breast Cancer on Correlation of Cytokine Concentrations in the Lymph with Structural Transformations in the Mesenteric Lymph Nodes
| Autor: | A N Sultanova, Vladimir I. Konenkov, A. V. Kabakov, D. N. Strunkin, Alexander Lykov, O. V. Poveshchenko, T. V. Raiter, A. F. Poveshchenko, N B Orlov, O. V. Kazakov, L F Gulyaeva |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Chemotherapy Pathology medicine.medical_specialty business.industry medicine.medical_treatment General Medicine medicine.disease General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Breast cancer medicine.anatomical_structure Cytokine Correlation analysis medicine Mesenteric lymph nodes Lymph business Surgical treatment 030217 neurology & neurosurgery Neoadjuvant therapy |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 171:68-73 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-021-05174-8 |
| Popis: | We performed a correlation analysis of the morphometry of mesenteric lymph nodes and cytokines of the thoracic duct lymph in chemically induced breast cancer (BC) and after surgical treatment of BC and neoadjuvant chemotherapy for BC according to the CMF scheme. After surgical treatment, correlations were found between the level of cytokines in the thoracic duct lymph and morphological changes in the mesenteric lymph nodes. The observed correlations can be a result of total resection of the tumor and increased immunomodulatory and antitumor action of cytokines. Comparison of the effect of chemotherapy and surgical treatment revealed correlations between cytokine concentrations in the lymph and structural changes in the lymph nodes, which can be related to weakening of local immunity and antitumor effect of cytokines. |
| Databáze: | OpenAIRE |
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