A Zn(ii ) complex with large channels based on 3′-nitro-biphenyl-3,5,4′-tricarboxylic acid: synthesis, crystal structure, fluorescence sensing of ATP, ADP, GTP, and UTP in aqueous solution and drug delivery
| Autor: | De-chun Zhang, Xia Li |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Aqueous solution GTP' Chemistry Inorganic chemistry Guanosine 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Phosphate 01 natural sciences Medicinal chemistry Uridine 0104 chemical sciences Coordination complex chemistry.chemical_compound Nitro General Materials Science 0210 nano-technology Adenosine triphosphate |
| Zdroj: | CrystEngComm. 19:6673-6680 |
| ISSN: | 1466-8033 |
| Popis: | A new coordination complex, namely, [Zn7L2(HL)2(OH−)4(H2O)2]·2H2O (1) [H3L = 3′-nitro-biphenyl-3,5,4′-tricarboxylic acid] was synthesized by a solvothermal reaction. Complex 1 has a 3D open framework with heptanuclear cluster [Zn7O2(OH)4] secondary building units (SBUs) and features an unexpected large porous structure with a pore size of 16.5 × 19.5 A2, which shows 37.0% porosity as calculated by PLATON. Adenosine triphosphate disodium salt (ATP), adenosine-5′-diphosphate disodium salt (ADP), guanosine 5′-triphosphate (GTP), or uridine 5′-triphosphate (UTP) was discriminated from other phosphate anions using fluorescence spectral analysis by adjusting the excitation wavelength at 287, 287, 306, or 337 nm. Complex 1 showed fluorescence sensing of ATP, ADP, GTP, and UTP in aqueous solution. In addition, complex 1 also exhibited a remarkable capacity for the anticancer drug 5-fluorouracil (5-FU), with a loading content of 46.5 wt%, and presented a slow controlled drug release. |
| Databáze: | OpenAIRE |
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