Anti-inflammatory Effects of Distylium racemosum Extract in a Mouse Model of Allergic Asthma
| Autor: | Jungeun Yang, Young Ho Kim, Sung-Jin Ko, Yongmun Choi, Jong Suk Lee, Yeon-Ju Nam, Jong-Heon Han, Kyuhee Park, Ji-Gweon Park, Myung-Jin Song, Su-Gyeong Kim, Hoo-Dhon Byun |
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| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Planta Medica International Open. 5:e48-e54 |
| ISSN: | 2509-6656 2509-9264 |
| Popis: | Allergic asthma is a complex disorder characterized by chronic airway inflammation. Patients with asthma often show poor adherence to corticosteroid therapy owing to prominent side effects, which provides a rationale to explore new drug classes with a better safety profile. In this study, we sought to discover natural products that inhibit the activity of phosphodiesterase 4, which is considered a potential molecular target for anti-inflammatory therapy. The screening of a plant extract library led to the identification of Distylium racemosum, which inhibited phosphodiesterase 4 activity in vitro and suppressed lipopolysaccharide-induced inflammatory signaling in cultured cells. In a mouse model of ovalbumin-induced allergic asthma, D. racemosum treatment significantly reduced inflammatory responses in the lung, as well as serum immunoglobulin E levels. Although the active constituents of D. racemosum extract and the exact mechanism underlying the in vivo action of D. racemosum remain to be elucidated, our results provide a basis for further investigation of D. racemosum extract as a novel anti-inflammatory agent for allergic asthma. |
| Databáze: | OpenAIRE |
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