Efficient synthesis of (R)-3-amino-1,1,1-trifluoropropan-2-ol via a Dakin–West reaction followed by enantioselective reduction

Autor:	Teresa W. Makowski, Carlos A. Martinez, Arun Ghosh, Lulin Wei
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Ketone Stereochemistry Organic Chemistry Asymmetric hydrogenation Enantioselective synthesis Alcohol Catalysis Inorganic Chemistry chemistry.chemical_compound Enzyme chemistry Physical and Theoretical Chemistry Dakin–West reaction
Zdroj:	Tetrahedron: Asymmetry. 19:2648-2651
ISSN:	0957-4166
DOI:	10.1016/j.tetasy.2008.12.001
Popis:	An efficient, chromatography-free asymmetric synthesis of (R)-3-amino-1,1,1-trifluoropropan-2-ol was developed for large scale production of a cholesterol ester transfer protein (CETP) inhibitor. The synthesis features a new efficient route to a β-amino trifluoromethylketone involving a modified Dakin–West reaction followed by an asymmetric hydrogenation or an enzymatic reduction of the resulting ketone to the alcohol.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::288e406ef8347a3a7082514b66f64d34 https://doi.org/10.1016/j.tetasy.2008.12.001 Zobrazit plný text záznamu Full Text from ScienceDirect